I wouldn't mind the devouring items (like, just clean it lol?) but I imagine most would.
Other ideas along with the bedbugs and other illnesses:
-The dirtier the tile, the less items you can store in them. (Maybe it 'buries' items instead of outright eating them, making you have to search around and dig through piles for them)
-Dirty rooms make you dirty quicker.
-Could also have a low chance of making certain electronics stop working or malfunction. Shower stops working, TV won't turn on, etc, and you have to call an electro tech character to come fix your stuff up.
-If things get really bad, it can spawn small critters like rats, roaches, spiders, whatever. These aren't that dangerous physically (might nip you and deal a tiny bit of damage and marks that let everyone know you're living in a dump) but can contract diseases, poison (spiders, milipedes). Rats could chew on your clothes and slowly damage them over days. (Another compromise to just eating items) Them and roaches could also slowly eat through your kitchenette's supplies, etc.
Basically, a lot of stuff to give cleaners and medical characters a lot more RP/mechanics. It would be super on theme to get a place on Red and the first time you walk in there's just trash, messes, roaches and stuff everywhere.